Veterinary Pharmacology & Toxicology

1. About the Department :

The Department was established in the year 1930 as Materia Medica. In 1960s, the Department was renamed as Veterinary Pharmacology and Toxicology. The Department of Veterinary Pharmacology & Toxicology is engaged in teaching and relevant researches since long back and a series of curricular and non-curricular research projects have been undertaken and successfully completed with some results of very high practical utility. Altogether 26 M.V.Sc. and 3 Ph.D Scholars have conducted their teaching and research successfully in this department and published more than 100 research papers. The Department of Veterinary Pharmacology & Toxicology is one of the well equipped departments of the college.

2. Mandate/ Objective :

  • To impart quality education in Veterinary Pharmacology & Toxicology.
  • To strengthen research in Veterinary Pharmacology & Toxicology.
  • To participate in the programmes of extension education and help in transfer of technology from lab. to land.

3. Faculty Position :

1. Dr. Nirbhay Kumar
Asstt. Professor
09006655117 drnkvet76@rediffmail.com
2. Dr. Archana
Asstt. Professor
09304137469 drarchana_pharma@rediffmail.com

3.

Dr. Rashmi Rekha Kumari

Asstt. Professor

---

rrkvet@gmail.com

4.

Dr. Kumari Anjana

Asstt. Professor

08521021617

dr_anjana@rediffmail.com

5.

Dr. Ramesh Kumar Nirala

Asstt. Professor

09507221894

nirala.ramesh@rediffmail.com

 

4. Teaching :

(i) U.G. Courses (VCI Syllabus)

Sl. No.

Course No.

Course Title

Credit hrs.

Semester

1.

VPT-311

General and Central Nervous System Pharmacology

2+1

V

2.

VPT-321

Autonomic and Systemic Pharmacology

2+1

VI

3.

VPT-411

Chemotherapy

2+1

VII

4.

VPT-421

Toxicology

2+1

VIII

 
(ii)
P.G. Courses (As per ICAR):

M.V.Sc. Courses :

Sl. No.

Course No.

Course Title

Credit hrs.

1

VPT 601

General Pharmacology

2+0

2

VPT 602

Autanomic and Autacoid Pharmacology

2+1

3

VPT 603

CNS Pharmacology

2+1

4

VPT 604

Digestive and Respiratory Pharmacology

2+0

5

VPT 605

Cardiovascular and Renal Pharmacology

2+0

6

VPT 606

Endocrine and Reproductive Pharmacology

2+0

7

VPT 607

Chemotherapy

2+1

8

VPT 608

Toxicology of Xenobiotics

2+1

9

VPT 609

Toxicology of Plants and Toxins

2+0

10

VPT 610

Pharmacological Techniques

1+1

11

VPT 611

Techniques in Toxicology

1+1

12

VPT 612

Ethnopharmacology

2+0

13

VPT 691

Master’s Seminar

1+0

 

 

Total

23+6=29

14

VPT 699

Master’s Research

20


Ph.D. Courses :

Sl. No.

Course No.

Course Title

Credit hrs.

1

VPT 701

Advances in Neuropharmacology

2+0

2

VPT 702

Autacoid Pharmacology

1+0

3

VPT 703

Pharmacology of Herbal Drugs

2+1

4

VPT 704

Drug Metabolism

2+0

5

VPT 705

Molecular Pharmacology

2+0

6

VPT 706

Pharmacokinetics

2+1

7

VPT 707

Pharmacogenomics

2+0

8

VPT 708

Immunopharmacology

1+0

9

VPT 709

Molecular Toxicology

2+0

10

VPT 710

Clinical Pharmacology

1+1

11

VPT 711

Clinical Toxicology

2+1

12

VPT 712

Ecotoxicology

2+0

13

VPT-713

Regulatory Toxicology

2+1

14

VPT 790

Special Problem

0+2

15

VPT-791

Doctoral Seminar-I

1+0

16

VPT-792

Doctoral Seminar-II

1+0

Total =

25+7=32

17

VPT 799

Doctoral Research

45

N.B. : A Ph.D. student may also take 600 series courses of M.V.Sc. if not studied during Master’s programme.

5. Research :

(i) Post Graduate Research (Curricular):

M.V.Sc. Degree awarded :

Sl. No.

Name of the Student

Year

Title of the thesis

1.

Dr. H.N. Jha

1975

Pharmacology of a few antimicrobiols with special reference to their distribution and excretion in goat.

2.

Dr. S.N. Pandey

1975

Studies on the Pharmacokinetics and toxicity of nitrofuran in goat.

3.

Dr. K.K. Sharan

1977

Pharmacokinetics of sulfamoxole and nitrofurantrin in buffalo calves

4.

Dr. V.K. Jha

1985

Pharmacokinetic study of doxycycline and Democlocycline in goat

5.

Dr. K.D. Yadav

1997

Pharmacokinetic study of ceftriaxone in healthy and febrile goats.

6.

Dr. A.K. Singh

1997

Pharmacokinetic study of cefatoximein healthy and febrile goats.

7.

Dr. M.K. Ansari

1997

Pharmacokinetic study of pefloxacin in healthy and febrile goat.

8.

Dr. C. S. Singh

1998

Pharmacokinetic study of cefazoxime in healthy and febrile goats.

9.

Dr. Saket Kumar

1998

Pharmacokinetic study of cefazoxime in healthy and febrile goats.

10.

Dr. Sudha Kumari

1998

Pharmacokinetic study of enrofloxacin and its interaction with paracetamol in goats

11.

Dr. Jai Prakash Narayan

1998

Pharmacokinetic study of enrofloxacin and its interaction with probenecid in goat.

12.

Dr. Sahid Prawez

2000

Pharmacokinetic study of cefutoxime in healthy and febrile goats (Capra hircus)

13.

Dr. A. K. Agrawal

2000

Pharmacokinetic study of amikacin in healthy and febrile goats.

14.

Dr. Uday Kumar

2001

Pharmacokinetic study of enrofloxacin in healthy and febrile goats.

15.

Dr. Shrawan Kumar

2001

Pharmacokinetic study of enrofloxacin in healthy and febrile goats.

16.

Dr. Param Bodh Kumar

2001

Pharmacokinetic study of tobramycin in healthy and febrile goats.

17.

Dr. Nitesh Kumar

2002

Pharmacokinetics of enrofloxacin and its interaction with diclofenic in buffalo calves

18.

Dr. B.K. Mukta

2002

Pharmacokinetic study of amikacin and its interaction with diclofenac in buffalo calves.

19.

Dr. Mukesh Kumar

2003

Pharmacokinetic study of amikacin and its interaction with paracetamol in buffalo calves.

20.

Dr. Sushma Lalita Baxla

2004

Pharmacokinetic study of gentamicin and its interaction with paracetamol in buffalo calves.

21.

Dr. Sanjeev Kumar

2004

Pharmacokinetics and toxicity of meloxican in goats

22.

Dr. Thakur Balwant Singh

2004

Pharmacokinetics of cefotaxime and its interaction with diclofenac in goats.

23.

Dr. Nirbhay Kumar

2004

Pharmacokinetics and toxicity of pefloxacin in goats.

24.

Dr. Deepak Kumar Prasad

2004

Pharmacokinetics of gentamicin and its interactions with diclofenac in goats.

25.

Dr. Anuradha Kumari

2004

Assessment of adverse effect of enrofloxacin in goats.

26.

Dr. Archana

2004

Assessment of adverse effect of invermectin in goats.

27.

Dr. Smita Sinha

2005

Pharmacokinetics and immunplogical effects of krtoprofen in goats

28.

Dr. Pravin Kumar

2005

Phrmacokinetic interaction of enrofloxacin with ketoprofen in goats

29.

Dr. Vijay Kumar Gond

2005

Pharmacokinetics and bio-availability of three commercial preparations of enrofloxacin after intravenous, intramuscular and oral administration in goats

30.

Dr. Dhiraj Kumar

2007

Pharmacokinetic and immunological interaction of enrofloxacin with ketoprofen with ketoprofen in goats

31.

Dr. Anuranjan Kumar Ravi

2007

Pharmacokinetic interaction of ciprofloxacin with meloxicam in goats

32.

Dr. Ramesh Kumar Nirala

2008

Pharmacokinetic and immunological studies of sparfloxacin in goats


Ph.D. Degree awarded :

Sl. No.

Name of the Student

Year

Title of the thesis

1.

Dr. N.C. Banerjee

1975

Studies on the Pharmacokinetics and toxicity of nitrofuran in goat.

2.

Dr. C. Jayachandran

1995

Pharmacokinetic study of  minocycline and oxytetracycline-Long Acting in healthy and febrile goat and buffalo calf.

3.

Dr. Nitesh Kumar

2005

Pharmacokinetics and immunological interactions of pefloxacin and meloxican in goats.


(ii) Research Projects :

List of research project undertaken :

Sl. No.

Name of the Research Project

Funding Agency

1

Distribution of sulphonamides in body fluid of goats.

U.G.C.

2

Pharmacokinetics of chemotherapeutic agents with particular reference to their distribution in the uterine fluid, milk and blood of she buffaloes.

D.S.T.

3

Pharmacokinetics and testing of dosage regimen of certain chemotherapeutic agents in healthy and febrile condition in buffalo calf.

I.C.A.R.

4

Studies on the occurrence and stability of aflatoxin in milk and milk products in different agro-climatic areas of Bihar

I.C.A.R.


Ongoing research Projects (Externally Funded)

Sl. No.

Name of the Research Project

Funding Agency

1

Outreach Programme on ‘Monitoring of Drug Residues and Environmental Pollutants’

I.C.A.R.


(iii) Research Achievements :
    • Loading dose, maintenance dose, and dosage intervals of many antimicrobials viz., different sulphonamides, penicillins (penicillin g & ampicillin), cephalosporins (cephazolin, cefuroxime, ceftizoxime & ceftrioxone), aminoglycosides (Streptomycin, gentamicin, tobramycin & amikacin), tetracyclines (oxytetracycline, doxycycline & minocycline) and fluoroquinolones (ciprofloxacin, pefloxacin, ofloxacin, enrofloxacin & sparfloxacin) were suggested in goat and buffalo in normal and febrile condition for the treatment of systemic, uterine, udder and urinary tract infections.
    • Normally, antimicrobials are combined with non steroidal anti-inflammatory drugs (NSAIDs) to treat microbial infections associated with various inflammatory conditions in man and animals. Various studies were conducted and dosage regimen on combination of these two groups of drugs were suggested for veterinarians for the effective treatment.
    • Studies on immunological interactions of antimicrobials with NSAIDs had shown that which antimicrobials should be combined for better treatment of inflammation (mastitis, endometritis and other inflammatory conditions) in cow, buffalo and goat.

6. Extension :

  • Participation in various extension activities of college and RAU (Kishan  Mela, Kishan Gosthi etc.)
  • Supplying pharmaceutical preparations of to Veterinary Clinics & Hospitals for therapeutic use in animals.
  • Several Radio & Television talks have been delivered by the faculty members of the Department from time to time.

7. Publications :

Research : National – 89, International – 14
Extension : NA
Books/Manuals : 2

8. Facilities :

    • HPLC laboratory with UV & Fluorescent detectors and Computerized control of the system with sufficient power back up is available and functioning in the Department to study the various drugs and their metabolites was set up under ICAR scheme which was recently upgraded and operated through computer program. Recently fluorescent detector has been purchased which is highly sensitive to detect aflatoxins and various insecticides in milk and tissues of animals.
    • A good microbiological assay laboratory with all available instruments like laminar flow, refrigerated centrifuge etc. had been purchased under DST & ICAR schemes.
    • Immunological studies were carried out. Facilities like deep freeze and various chemicals were purchased under SAU fund of ICAR. RAU also supported the programme for carrying out P.G. and Ph.D. studies with some grants.

9. Seminar/Symposia organized :

The Department of Veterinary Pharmacology & Toxicology organized the 6th Annual Conference of Indian Society of Veterinary Pharmacology & Toxicology (ISVPT) and National Symposia on “Emerging role of biotechnology in production of veterinary drugs”, “Recent trends in development of herbal drugs: Challenges and Opportunities” and “Toxicological impacts of environmental and industrial chemicals” from 23-25 Nov. 2006 with financial assistance of DBT, DST, ICMR and CSIR.

10. Any other information :

    • Dr. Allauddin Ahmad, Ex-Head of this Department became Vice-Chancellors of SKUAS&T, J&K and Hamdard University. He also occupied the position of Dy. Director General (Education), ICAR.
    • Research work of the Department quoted by the standard International text book of Veterinary Pharmacology i.e. Adams ‘ The Veterinary Pharmacology and Therapeutics’ 8th Edition, 2000 (Page No. 803, 817,827, 835 & 839).
    • Dr. Mani Kant Singh and Dr. Shankar Dayal Singh, Ex-Chairmen of this Department occupied the positions of Dean-cum-Principal of Bihar Veterinary College, Patna.